Download Atlas of Endometrial Histopathology by Gisela Dallenbach-Hellweg M.D., F.I.A.C., Hemming Poulsen PDF

By Gisela Dallenbach-Hellweg M.D., F.I.A.C., Hemming Poulsen M.D. (auth.)

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Epithelial Metaplasia Squamous Metaplasia and Ichthyosis Squamous Metaplasia. Nodules of squamous epithelium arise from the glandular epithelium of irregularly proliferating or cystically dilated hyperplastic glands. Such nodules may develop focally or diffusely and may be found in all endometrial layers (see Fig. 104). All transitional stages are encountered, from a few small nodules to extensive metaplasia, which may also involve the surface epithelium (ichthyosis). When the surface epithelium becomes involved (Fig.

Van Gieson stain, XIOO Circulatory Disturbances Pathologic Edema In pathologic edema (Fig. 65) the endometrial glands are widely separated and the stromal cells pushed apart by small lakes of edema fluid or diffuse accumulation of edema between them. The reticulin fibers are extremely scanty and also pushed far apart. The small lymphatic channels in the stroma are distended. The appearance of glandular and stromal cells is otherwise within normal limits. Morphologic Differential Diagnosis. Pathologic edema must be differentiated from physiologic variations in the vascular and lymphatic circulation during the normal menstrual cycle.

Fourteenth day after ovulation. H & E, x 100 Normal Menstrual Cycle 31 weg 1964). The endometrial granulocytes, which have lost their granules, can be recognized at this late stage of dissolution only by their characteristic lobulated nuclei and their vacuolated cytoplasm. The surface epithelium is low and appears inactive. Relaxin has been located biochemically and immunohistochemically in the decidua and in pre decidual endometrium (Bigazzi et al. 1980; BryantGreenwood 1991; Lippert et al. 1993; Dallenbach-Hellweg and Dallenbach 1993).

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