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By Edward S. Meek M D, Ch B, MRC Path (auth.)

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Borrelidin inhibited plaque formation in vitro by the viruses of Newcastle disease, influenza and encephalomyocarditis; no activity was found in vivo against influenza, EMC or ectromelia in mice. The structure of borrelidin lias been studied by ANDERTON and RICKARDS (1965) who consider that it is probably an antibiotic of the macrolide group but with some structural features whim are unique within this group. 4. Plant Sources Plants have provided the basis for traditional treatment of all types of disease, and offer an enormous potential source for antineoplastic agents (HARTWELL, 1960).

JUDGE (1966) tested a clam extract against Moloney and Friend viruses in vivo, and found that the mean survival time was increased in the animals with Moloney leukaemia, but that whilst splenomegaly was inhibited in those infected with Friend virus, there was no increase in survival. LI et al. 1. 1210. However, the activity is less than that of methotrexate; for this reason, and also because of its toxicity, the authors do not suggest that this preparation would be useful for human leukaemia. A number of extracts prepared from various species of marine algae have been tested by STARR et al.

The intraperitoneal route proved to be superior to the subcutaneous in the induction of immunity; a significant degree of resistance could be demonstrated after eight months. Mice immunised with irradiated Sarcoma 180 cells were cross immune to the Ehrlich carcinoma cells. LARSON et al. (1966) have pointed out that immunological control of virusinduced tumours might be established in three ways. One is by inducing resistance to the initial viral infection; the second by immunisation against the homologous tumour-specific antigen prior to the appearance of the neoplasm; the third by immunisation against secondary growth using autochthonous tumour vaccine.

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