By Irvin M. Modlin MD PhD FRCS(Ed) FRCS(E, George Sachs MD ChB DSc
This textbook explores the heritage, biology, and remedy of acid similar ailments, together with gastric and duodenal ulcer illness, gastroesophageal reflux illness (GERD), and the function of H. pylori. The textual content bargains thorough insurance of the subject material, with an in-depth ancient and organic concentration. equivalent concentration is given to the biology and pharmacology of acid secretion and to the categorical sickness states of ulcers and GERD. This variation is stuffed with new full-color scientific illustrations of all points of this topic.
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Extra resources for Acid Related Diseases: Biology and Treatment
The phosphorylation site was observed to be at Asp 386. FITC covalently labels the Na,K and the gastric H,K ATPases in the absence of ATP. The binding site of FITC was at Lys 518. However, several additional lysines, such as those at positions 497 and 783, were shown to react with FITC during the inactivation of the Na,K ATPase and to be protected from reaction with FITC when ATP was present in the incubation. Based on these data, similar lysines of the H,K ATPase could be near or in the ATP-binding site, which is, therefore, formed by several nonadjacent stretches of the cytoplasmic amino acid sequence.
J Med Chem 1995;38:2763-2773. Ito S. Functional gastric morphology. In: Johnson LR, ed. Physiology of the gastrointestinal tract, 2nd ed, vol 1. New York: Raven Press, 1987:817. Ito S, Schofield GC. Studies on the depletion and accumulation of microvilli and changes in the tubulovesicular compartment of mouse parietal cells in relation to gastric acid secretion. J Cell Biol 1974;63:364. Jewell EA, Lingrel JB. Site directed mutagenesis of the Na,K ATPase. Consequences of the substitutions of negatively charged amino acids localized in the transmembrane domains.
Martin was sent to Fort Crawford on the Upper Mississippi River, where Beaumont was then stationed. During the next 2 years, many experiments were performed, but not long afterward, St. Martin and his family became so homesick and discontented that they returned to Canada. William Beaumont (right) was born on November 25, 1785, in Lebanon, Connecticut, and began his study of medicine at the age of 22 years. During the War of 1812, he accepted a position in the army as an acting surgeon's mate and thereafter returned to civilian life.