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By Professor J. R. Trounce (auth.), Professor J. R. Trounce (eds.)

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It acts within 30 minutes and lasts for 4-5 hours. The Analgesics Therapeutic uses. Dose: 7S-1SO mg orally. It is used chiefly in conjunction with aspirin or paracetamol. Contra indications and side effects. Similar to morphine but appears not to be addictive. Table 4 Morphinans and Benzmorphans Related drugs with Useful analgesics other uses Morphinans Levorphanol (l-methorphan) d-Methorphan (anti-tussive) Levallorphan* Benzmorphans Phenazocine Pentazocine * Narcotic antagonist. Levorphanol Pharmacological action.

Some patients develop an acute intrahepatic cholestatic jaundice which usually clears up when the drug is stopped. It very rarely progresses to cirrhosis. Blood dyscrasias, leucopaenia, granulocytopenia and agranulocytosis are rare but acute complications with high mortality rates; usually heralded by sore throat, malaise and fever. Myasthenia gravis may be precipitated or exacerbated. Promazine Pharmacological action. Similar to chlorpromazine; the chlorine atom of the phenothiazine nucleus is in this agent, replaced by hydrogen.

And those affected by Parkinson's disease. It is usually combined with an anti-parkinsonian drug (see above). Its contraindications are glaucoma and urinary retention. Depression, loss of appetite and a symptomatic triad of sweating dehydration and hyperthermia have been described. Triperidol Pharmacological action. Similar to haloperidol. Therapeutic action. This drug is more potent; oral dosage ranging from 1-3 mg a day. Contra indications and side effects. Similar to those of haloperidol, but with greater extra-pyramidal effects.

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